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The truck lost power while on the road.  Warning on dash are check engine soon, slip and 4WD. The vehicle was on 2WD.  

When I tried to run the engine it missed fire and lots of smoke out of the tail pipe.

OBD2 scanner shows code "P0603"

                                       "Fuel System1    OL"
                                       "Fuel System2    OL"

I have no clue what those means.
Vehicle: 2006 Nissan Frontier Nisma Offroad V6 engine.

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HI there,

The code indicates there is a power issue to the ecm. This is fuse #53 in the IPDM which is the large fuse and relay box under the hood. If the ecm is not getting power through the IPDM it could be the IPDM itself causing the issue.

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