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code p0300 is coming up changed wires plugs, connectors

Vehicle: 2004 checy surburban 1500 2wd 5.3 no flex fuel

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HI there,

If you have a p0101 that is for a faulty mass air flow sensor. This can affect the fuel mixture and cause the misfire codes.

If all you have is the P0300 multiple misfire code, then check for an intake manifold gasket leak. It's a pretty common issue on this engine.

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