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I have a 2008 Accord EX-L Coupe with 78,652 miles on it. After a long road trip on the highway, the check light stared flashing, and the VSA light came on. The OBD II reader detected the following codes: PO300, PO303, and PO306. I understand these are misfire codes, but can they all be related or could the PO306 code be unrelated to the other two codes?

Vehicle: 2008 Honda Accord EX-L V6

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P0300 Random misfire

P0303 Misfire number 3 cylinder

P0306 Misfire number 6 cylinder

Whenever the CK ENG LT comes on, the VSA is disabled, this is for safety reason, the vehicle is no longer operating at manufactuer specifications. You can have just one igntion coil that fails and it would become progressive and set other cylinder to misfire.

 Clear the code, allow to idle , what you may have is just one igntion coil that is faulty.which should set a misfire code

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