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On my 2005 GMC Sierra 2500 random misfire was detected and code P0300 can a leaking exhaust manifold cause this alarm?

Vehicle: 2005 GMC Sierra 2500

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Yes, an exhaust leak could cause a random misfire, if you know where the leak is take it to a muffler shop and have them weld it or place a gasket whichever the problem is
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P0300 GMC Code - Cylinder Misfire Detected Random Cylinders

Read more: https://www.autocodes.com/p0300_gmc.html

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