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What does code P0303 on a 2008 F-150 mean, I have replaced plugs and wires

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I have replaced plug and wires and still have problem of engine chugging at acceleration over 50 mph. same code of P0303.

Vehicle: 2008 F-150

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P0303 Misfire number 3 cylinder

Misfire over 50 MPH the coil causing problem,

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