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2001 s10blazer w 2 codes codes are po300 and po327 where do i start

Vehicle: 2001 s10blazer 4.3

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Hi there,

P0300 is a multiple misfire code. This is usually a result of needing a tune up or even sometimes a leaking intake manifold gasket. The other code is for the knock sensors. I would start by eliminating the misfires, then clear the codes and if the 327 code comes back, replace the knock sensors.

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