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All 3 codes are detected at the same time. Could this be because of a timing belt issue or spark plugs?

Vehicle: 2001 Lexus LS 430

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if you have not replaced spark plugs in 50k miles replace the spark plugs first and check the ignition coil on bank 1, 3, 5

 

2001 Lexus LS 430 v8 firing order and cylinder number

timing belt is due 90k miles, or every 7 years if you timing is off that can also cause a misfire.

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