P0300 Ford - 05 ex?pedition 5.4L

Question

P0306 pulled, swapped cop #5 with #6, then p0300 came up.

Answer 1

P0300 Random misfire

Anything that got disconnected, has to be reconnected. If one injector connector is not properly connected it can set a P0300, so can one poorly connected ignition coil

 Check the injector connector poor connection here can set a P0300

 Igntion coil not properly connected, would set a P0351 in most cases, but can set a P0300