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On my 1998 Nissan Pathfinder SE 3.3L, what's the most common to cause a problem P0300?

Vehicle: 1998 Nissan Pathfinder SE 3.3L

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if there is not intake leak, most common problem is most likely spark plug, or clogged fuel injector 

if you have not replace the spark plugs as a normal maintance you can start there. (use oem NGK spark plugs dont use cheap ones)

 

Possible causes
- Faulty spark plug (s) 
- Faulty ignition coil (s) 
- Clogged or faulty fuel injector (s)
- Intake air leak
- Fuel injectors harness is open or shorted
- Fuel Injectors circuit poor electrical connection
- Ignition coils harness is open or shorted
- Ignition coils circuit poor electrical connection
- Insufficient cylinders compression
- Incorrect fuel pressure

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