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I just changed the spark plugs and intake gasket seems to be good. Coils a 2 month old. Maf is new.
Should I put new intake gasket? If so wich one ? The middle one or both? And can a vacuum leak cause a random missfire?

Vehicle: altima 2003 v6 3.5

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Yes a vacuum (intake) leak can cause a random misfire

bad injector/s may also cause a p0300 or bad ignition coil/s

also a bad fuel pump 

p0300 is hard to diagnose, unless you know what to look for next 

 

 
Possible causes
- Faulty spark plug (s) 
- Faulty ignition coil (s) 
- Clogged or faulty fuel injector (s)
- Intake air leak
- Fuel injectors harness is open or shorted
- Fuel Injectors circuit poor electrical connection
- Ignition coils harness is open or shorted
- Ignition coils circuit poor electrical connection
- Insufficient cylinders compression
- Incorrect fuel pressure
 

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