P1300 Ford -

Question

2004 expedition sets p1300 kills the a/c ground to the compressor

Answer 1

P1300 Misfire'

What you have is a misfire condition when this misfrie occurs the A/C is disabled, The ECM does this to protect the catalytic convertor, You will have to check the ignition coil boot and the sparkplug well for any water intrusion or worn sparkplug boot allowing its secondary ignition to seek ground.