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I don't know the engine type.
Vehicle: 2006 pilot 2WD

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Hi there

This code is for either a random misfire or multiple misfires. Usually if all you have is a P0300 it's a random misfire. This means the computer knows one of the cylinders is misfiring, but doesn't know which one it is. Sometimes it takes some time for it to come through, other times you have to inspect the ignition components to try and locate the issue. Could be the result of bad spark plugs, a plug wire or ignition coil.

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